TERT and cancer: Here, we performed an in silico pan-cancer analysis of TERT regulation by using an evolved version of the “Mixed Integer linear Programming based Regulatory Interaction Predictor” (MIPRIP, version 2.0) to predict TFs regulating the gene expression of TERT. The new version bases on MIPRIP (https://github.com/KoenigLabNM/MIPRIP) which was previously developed to identify regulatory interactions that best explain the discrepancy of telomerase transcript levels in Saccharomyces cerevisiae between yeast deletion strains with shorter telomeres and strains with wild-type telomere length.