The enriched members of this pathway for the ESCA-specific FFL were 4 TFs, E2F1, E2F3, MYC, TFDP1 and 1 gene GADD45B. And the enriched members of this pathway for the STAD-specific FFL were 4 TFs, E2F1, SMAD4, SMAD2, MYC and 3 genes which included CDKN1C, CDK1, GADD45B. The common members which were 2 TFs, E2F1, MYC and 1 gene GADD45B, were all related to both of two types of cancer. Here, SMAD4 is linked to cancer.