At 4 weeks post-stroke, functionally connected genes pertaining to cell population proliferation (Igf1, Ptprc, Timp1, Cxcl12, and Mmp2), wound healing (Timp1, Igf1, Sparc, Tgfb1, and Col1a1), response to estradiol (Igf1, Col1a1, Igf2, Mmp2, and Tgfb1), response to organisms (Igf1, Spp1, Col1a1, Fos, and Tgfbr2), aging (Igf1, Tgfb1, Timp1, Mmp2, and Fos), response to cytokines (Cxcl12, Cd44, Mmp2, Spp1, and Col1a1), multicellular organismal processing (Igf1, spp1, Mmp2, Col1a1, and Sparc), and nervous system development (Cd44, Igf1, Mmp2, Spp1, and Cxcl12) were upregulated. Here, SPP1 is linked to stroke disorder.