At 4 weeks post-stroke, the top 10 gene products in the PPI network were Cd44 (degree = 17), C1qb (degree = 15), Fcgr2b (degree = 14), Spp1 (degree = 12), Cd74 (degree = 12), C4a (degree = 12), C1qa (degree = 12), C3 (degree = 10), Cd14 (degree = 10), and Itgb2 (degree = 10). The gene discussed is SPP1; the disease is stroke disorder.