Hypermethylation of cg26732804 (HHEX) and cg14397361 (NELFB) was significantly associated with the presence of lymph node metastasis (odds ratio [OR], 7.50; 95% CI, 1.61 to 34.95; p = 0.01 and OR, 5.50; 95% CI, 1.16 to 26.14; p = 0.032, respectively). This evidence concerns the gene NELFB and metastatic malignant neoplasm in the lymph nodes.