SIK3 and metastatic neoplasm: Among the top 50 DMPs, two probes, cg11694510 and cg09923443, localizing to the promoter regions of IFITM1 and SIK3, respectively, showed profound hypomethylation in the primary tumors compared to the metastatic tumors, highlighting the role of these genes in early stromal invasion and initiation of metastasis.