At day 21 of PEPs inhalation, Tnnc1 was down-regulated (p < 0.05) in rat lung, with involvements in cardiac muscle contraction and tissue morphogenesis, dilated cardiomyopathy, and hypertrophic cardiomyopathy (Table 1 and Table S2). The gene discussed is TNNC1; the disease is hypertrophic cardiomyopathy.