To obtain a score of “+2” the threshold was set at a total of 50 entries for solid (e.g., EGFR c.2303G>T; p.(Ser768Ile): 265 entries), and 10 for haematological tumours (e.g., SF3B1 c.2219G>A; p.(Gly740Glu): 15 entries), irrespective of the tumour type in which the variant was detected. Here, SF3B1 is linked to neoplasm.