SERPINE1 and type 1 diabetes mellitus: In addition, differences in coagulatory protein levels and clot parameters were found between males and females with T1DM or T2DM: indeed, fibrinogen and PAI-1 concentrations are higher in females with T2DM than in males with T2DM, and after correcting for those factors, females still had more compact clots that were resistant to fibrinolysis than males [65], However, another study with fewer individuals found unchanged fibrinogen levels and reduced PAI-1 levels in females with T2DM [66].