Proteins with elevated concentrations in both types of diabetes include von Willebrand factor (vWF) [10,11,12], (pre)kallikrein [13,14], factor V [15], (activated) factor VII [15,16,17], factor VIII [15,18], factor X [15], factor XI [14], prothrombin [15], and fibrinogen [19,20,21] (although a study has also reported its reduction in T1DM [22]). Here, KLK4 is linked to type 1 diabetes mellitus.