The pro-fibrinolysis protein, tissue plasminogen activator has an increased concentration in individuals with glucose intolerance [36] and in individuals with T1DM [37] or T2DM [24], but its availability is decreased because of the elevated concentration of plasminogen activator inhibitor 1 (PAI-1) associated with glucose intolerance in non-diabetic individuals [36] and with individuals with T2DM [10,19,20,24,38]. This evidence concerns the gene SERPINE1 and type 2 diabetes mellitus.