Simultaneously to changes in pro-coagulation proteins, several anticoagulation proteins have a reduced plasma concentration in both types of diabetes, including protein C [15,19,28,29] and protein S [30], but thrombomodulin [29,31] has an elevated concentration in both types of diabetes and tissue factor pathway inhibitor levels are elevated in T2DM [16]. This evidence concerns the gene THBD and type 2 diabetes mellitus.