Furthermore, individuals with T1DM have the same levels of S1P and apolipoprotein M in total HDL as controls, but the HDL-associated apolipoprotein M/S1P complex move to a different subset of HDL, from buoyant HDL to dense HDL, where it has reduced anti-inflammatory effects due to altered S1P1 receptor activation [133]. Here, APOM is linked to type 1 diabetes mellitus.