Transduction with mutant IDH1 led to a reproducible and significant radio-sensitization in the glioblastoma cell line U87-MG and astrocytes SVGp12 (p < 0.001) (Figure 2e), while the survival curves of vector control and IDH-mutated patient derived cell line HT7606 did not systematically differ. Here, IDH1 is linked to glioblastoma.