In accordance with our findings in U87-MG and HT7606, the QPRT expression was variable in these patient-derived glioma cells: 1/3 IDH-mutant and 5/5 IDH-wildtype glioma cell models expressed QPRT (3/5 with high and 2/5 with low QPRT levels) (Figure 4c and Supplementary Figure S6). Here, IDH1 is linked to central nervous system cancer.