Our findings showed that haploinsufficiency of Foxo1 accelerated the occurrence of skin papilloma, particularly in CR conditions (WT-CR vs. Foxo1+/− CR, p = 0.0103 by log-rank test; Figure 2A), confirming the role for FoxO1 in the tumor-inhibiting effect of CR, as in Nrf2. This evidence concerns the gene FOXO1 and skin papilloma.