ATP2B4 and Alzheimer disease: Using several models, including the adult and aged mouse brain, Alzheimer’s disease-affected human brain, SH-SY5Y human neuroblastoma cells, as well as purified synaptosomal PMCA from pig cerebrum, Mata’s group discovered that PMCA activity was inhibited by tau protein and amyloid-β peptides, and PMCA4b appeared to be the most sensitive target for that inhibition [40,41,42,43].