LEP and metabolic dysfunction-associated steatotic liver disease: NAFLD can be experimentally induced by animals with genetic changes (combined or not with hypercaloric diets), such as in leptin-deficient (OB/OB) mice models, which have an alteration in the gene responsible for leptin production, and leptin receptor deficient (DB/DB) mice, which have a mutation in the receptor coding gene for this same hormone [12].