Besides the cell division-associated genes like CCNB2 and BUB1B, we also found genes such as TPX2 [30], BIRC5 [31], TOP2A [32], SPAG5 [33] and HMGB1 [34], were among the top 10 highly expressed genes in the cell subset (Figure S6A, Table S4), which were reported to be directly or indirectly associated with cancer invasion. The gene discussed is BUB1B; the disease is cancer.