TOP2A and cancer: Besides the cell division-associated genes like CCNB2 and BUB1B, we also found genes such as TPX2 [30], BIRC5 [31], TOP2A [32], SPAG5 [33] and HMGB1 [34], were among the top 10 highly expressed genes in the cell subset (Figure S6A, Table S4), which were reported to be directly or indirectly associated with cancer invasion.