Expression and activation of the signal transducer and activator of transcription-3 (STAT3) has been reported as a key regulator of this kind of tumor, so a chimera aptamer antagonistic for PDGFRbr (a receptor overexpressed in glioblastoma, as well as other tumor types) carrying siRNA for STAT 3 was designed. Here, STAT3 is linked to glioblastoma.