A novel targeted delivery platform to mediated gene-silencing in cancer cells was described by Ayatollahi et al.; the 10-bromodecanoic acid (10C) and 10C-PEG was loaded with shRNA plasmid for specific knockdown of BCL-xL protein and was conjugated to AS1411 aptamer for targeting to nucleolin on cancer cells [30]. This evidence concerns the gene BCL2L1 and cancer.