Indeed, we have experimental data showing that FACSorted CD133low WiDr cells over time re-express the CD133 receptor on the plasma membrane (unpublished), which is in agreement with Peickert et al. that showed that CD133low HT-29 and SW620 colorectal adenocarcinoma cells quickly re-express CD133 on their surface both in vitro and in vivo [51]. Here, PROM1 is linked to colorectal adenocarcinoma.