During obesity and insulin resistance, the adipose tissue presents (i) a diminished ability to capture glucose due to the downregulation of GLUT4, the major insulin-regulated glucose transporter [26,27], and (ii) an increased lipolysis and release of fatty acids and glycerol [28,29], shifting down the lipogenic process. This evidence concerns the gene SLC2A4 and obesity due to melanocortin 4 receptor deficiency.