Nagasawa, Yotsu-Yamashita, and co-workers evaluated the NaV-inhibitory activity of SEA (9) by utilizing neuroblastoma Neuro 2A cells, which is known to express NaV1.2, 1.3, 1.4, and 1.7 [70], and found moderate inhibitory activity with an IC50 value of 47.0 ± 1.2 nM (Figure 6B) [67]. The gene discussed is SCN2A; the disease is neuroblastoma.