SCN2A and neuroblastoma: Beside SEA (9), they synthesized dicarbamoyl SEA (dcSEA, 31), 11-saxitoxin ethyl ethanoate (SEE, 32), and 11-benzylidene STX (33a), and evaluated their NaV-inhibitory activity in mouse neuroblastoma Neuro 2A cells, which is known to express NaV1.2, 1.3, 1.4, and 1.7 [70].