For newly diagnosed older AML patients, new treatment regimens have been developed in recent years, such the combination of the BCL-2 inhibitor venetoclax with hypomethylating agents (HMA) (e.g., azacytidine/AZA and decitabine/DAC) or the combination of the Hedgehog pathway inhibitor glasdegib with LDARAC both of which showed significant clinical activity with reduction in the risk of death in randomized Phase II clinical trials [54,55]. The gene discussed is BCL2; the disease is acute myeloid leukemia.