CNP-Cur and Dex-CNP-Cur formulations induce the neuroblastomas to increase the ROS production and dramatically decrease the ratio of Bcl-2/Bax (Bcl-2 stands for anti-apoptic factors and Bax is apoptosis-inducing gene) which consequently triggers the release of cytochrome C, guide to caspase 3/7 activation, and apoptosis [61]. This evidence concerns the gene CNP and neuroblastoma.