As Rho GTPases and the serine/threonine kinases, ROCK1 and ROCK2 have been implicated in cytoskeletal regulation involved in cell motility, invasion and proliferation, all key steps in metastasis [8], we investigated the therapeutic potential of targeting the Rho/ROCK pathway in medulloblastoma, which to our knowledge is unexplored. The gene discussed is ROCK1; the disease is medulloblastoma.