TP53 and neoplasm: Among the top downregulated hallmark pathways were several gene sets important for tumor progression and metastasis such as signaling through tumor necrosis factor α (TNFα) via nuclear factor κβ (NFκβ,), transforming growth factor β (TGFβ), P53, phosphatidylinositol-3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR), mitotic spindle, epithelial to mesenchymal transition (EMT) and hypoxia (Table 1).