Western blot analysis for ROCK1 and ROCK2 in a panel of medulloblastoma cell lines showed evident levels of protein expression from at least one of the two ROCKs in all cell lines analyzed, as well as activation of the downstream target MLC, however very low in the D458 cell line (Figure 1D, Figure S1B,C). The gene discussed is ROCK1; the disease is medulloblastoma.