HMGA2 and colorectal carcinoma: Chen et al. have shown elevated expression of miR-1249 is associated with decreased CRC cell metastasis and angiogenesis by blocking of VEGFA and high mobility group AT-hook 2 (HMGA2) [47]; Moreover, by in vivo angiogenesis assays, they have demonstrated that an inverse correlation between MiR-1249 and CD31 which is linked to anti-angiogenic functions of miR-1249.