MiR-194 is involved in EMT induction and invasion in CRC cell lines [135]; nevertheless, its downregulation in CRC tissue compared to adjacent non-cancerous tissue and its association with inhibition of cell proliferation via regulation of the MAP4K4/c-Jun/MDM2 signaling pathway indicate tumor suppressive features of miR-194 [136]. This evidence concerns the gene MAP4K4 and colorectal carcinoma.