Several glycosyltransferase genes involved in ganglioside synthesis were found to be significantly upregulated, including GM3 synthase (St3gal5) and GM2 synthase (B4galnt1), a lack of which has been linked to hereditary epilepsy [31] and spastic paraplegia, respectively [32] (Figure 3). The gene discussed is ST3GAL5; the disease is Spastic paraplegia.