IHC analysis showed not only that SOX2 expression was significantly higher in the PRL-3-high group than in the PRL-3-low group but also that both expression patters were well co-localized (upper panel, a pair of serially sliced samples) and there was a tight correlation between PRL-3 and SOX2 expression in these tumor samples (Figure 7A). Here, PTP4A3 is linked to neoplasm.