TP53 and cancer: In this process, the cellular localization of PRL-3 indeed is critical (Figures 4A and 4B), enlightening an important consideration of a key protein's location with its specific function in cancers or other diseases, for instance, of p27 and p53, whose locations are linked to various outcomes in cancer progression (Larrea et al., 2009, Muller and Vousden, 2014).