Phosphatase of regenerating liver 3 (PRL-3) is found upregulated in metastasis sites of various cancers, and a higher PRL-3 level is related to poor prognosis in several cancers including colon, ovarian, and breast cancer and leukemia (Al-Aidaroos and Zeng, 2010, Peng et al., 2004). The gene discussed is PTP4A3; the disease is cancer.