No significant associations were found between the polymorphism and any MACE outcome before and after adjustment for age, gender, education, accommodation, Beck Depression Inventory scores, previous history of depression, hypertension, diabetes, hypercholesterolemia, obesity, smoking, past history of ACS, ACS diagnosis, Killip class, left ventricular ejection fraction, and serum levels on troponin I, creatine kinase-MB, and hs-CRP at baseline. Here, CRP is linked to obesity due to melanocortin 4 receptor deficiency.