The rationales for choosing BDNF gene were that serum BDNF plays a crucial role in cardiovascular disease by enhancing angiogenesis, regulating vascular flow, and promoting the revascularization of ischemic tissue [9,10]; and that BDNF expression is influenced by genetic polymorphisms, including a single-nucleotide polymorphism at nucleotide 196G/A, which results in the substitution of valine by methionine at codon 66 (val66met) of the pro-BDNF molecule, and thus presence of the met allele has been linked to decreased activity-dependent secretion of BDNF [11]. This evidence concerns the gene BDNF and cardiovascular disorder.