We found that the odds of overall osteoporosis among elderly women carrying CG/CC genotype of VDR rs3782905 were significantly higher than those among carrying TNF-α rs1800629 GG genotype (adjusted OR: 3.66 [95% CI: 1.62–8.26] but not among those carrying TNF-α rs1800629 AG/AA genotype. This evidence concerns the gene VDR and osteoporosis.