All of the patients with COPD with asthma-like features met the criteria for asthma symptoms, whereas 9 (31%) had bronchodilator reversibility, 17 (59%) had blood eosinophilia, 13 (45%) had high levels of serum IgE, and 2 (7%) had a history of allergic rhinitis. The gene discussed is IGHE; the disease is asthma.