The fact that all myeloid cell subsets, and in particular neutrophils and Ly6Chi monocytes are the primary source of IL-23 during systemic candidiasis (S10 Fig) and likewise express highest levels of Il23r transcripts (Fig 7E–7G) indicates that IL-23 possibly acts in partially autocrine but not cell-intrinsic manner within the myeloid compartment, along a novel and not yet fully characterized pathway. This evidence concerns the gene IL23R and candidiasis.