Despite the very high fungal burden in IL-23-deficient mice at this time point, we found to our surprise that the inflammatory infiltrates were largely absent from C. albicans foci and throughout the kidney of Il23a-/- mice at 48h post infection, while dense inflammatory cell clusters further accumulated in the infected kidney of WT mice over the same period of time (Fig 2B). The gene discussed is IL23A; the disease is infection.