Smooth muscle cells maintain plasticity to evolve from a quiescent, contractile phenotype towards a synthetic phenotype, characterized by proliferation, migration and extracellular matrix (ECM) remodelling.28 TGF‐β regulates SMC differentiation during embryonic development and participates in postnatal phenotypic switching.29, 30 Crosas‐Molist et al19 previously characterized phenotypic changes in MFS patients, revealing increased levels of contractile proteins and collagen I via histologic and protein‐based methods. Here, TGFB1 is linked to Marfan syndrome.