Notch 1‐4 mRNA levels were significantly decreased in BAV aortic specimens compared to normal tricuspid aortic valve aortas.23 Similarly, reduced Notch 1 and 3 gene expression levels were reported in human abdominal aortic aneurysm samples.24 We hypothesize the Notch pathway incites productive tissue remodelling in response to MFS aneurysm formation and affords a provocative avenue for therapeutic intervention via forced Notch3 overexpression. The gene discussed is NOTCH1; the disease is aneurysm.