TGFB1 and aneurysm: While ERK signalling has been implicated as a driver of aneurysm pathogenesis in the Fbn1C1039G/+ MFS model,15, 35 ERK activation was significantly enhanced with losartan and anti‐TGF‐β therapy and coincided with aneurysm prevention in the more aggressive Fbn1mgR/mgR mouse model.36 Furthermore, ERK inhibition exacerbated SMC pathology in an induced pluripotent stem cell‐derived model of MFS by increasing apoptosis and reducing proliferation.37 Importantly, whether ERK signalling drives aneurysm formation in the human disease has not been firmly established.