TNF and cancer: {FIG7} Previously TNF‐α has been implicated as a potential regulator of adiponectin expression in WAT but not in the context of cancer.32, 33, 34 Transwell co‐culture of myeloma cells with BMAds was found to increase activation of JNK, p38MAPK, and ERK1/2, pathways which have previously been implicated in TNF‐α‐mediated suppression of adiponectin in WAT35 (Fig. 7B).