Ablation of RAPTOR strongly inhibited c‐Myc liver tumor formation via quenching mTORC1 cascades and downregulating SLC1A5 and SLC7A6, which further weakened mTORC1.7 LncRNA MALAT1 contributed to HCC development by enhancing the translation of the metabolic transcription factor TCF7L2. The gene discussed is RPTOR; the disease is hepatocellular carcinoma.