CXCL8 and systemic lupus erythematosus: In addition, we found that the levels of TNF-α, IL-8, IL-1β, and IL-10 in SLE PBMCs were markedly downregulated by miR-98 mimic transfection (Figure 3(d)) and that were markedly upregulated when miR-98 was suppressed (Figure 3(e)).