The use of allogeneic heat shock-conditioned tumor cell lysates provides a vast number of different tumor-associated antigens described for melanoma and also delivers different damage-associated molecular patterns (DAMPs) induced by the heat shock, such as high mobility group box-1 (HMGB1) and plasma membrane translocated calreticulin (CRT) necessary for the proper maturation, activation, and cross-presentation of tumor-associated antigens by DCs, enhancing their antitumor-induced responses [28–30]. The gene discussed is CALR; the disease is melanoma.