APOH and autoimmune polyendocrinopathy: ACA in autoimmune disease and antiphospholipid syndrome (APS) is within the autoimmune range, and its target antigen is phospholipid-binding protein, which can cause coagulation disorder; syphilis and other infectious diseases contain nonimmune ACA, whose target antigen is cardiophosphate, and it does not depend on plasma proteins such as β2GPI.