Pathologically, PAD4 is distinct from other PADs as it is involved in many autoimmune disorders such as rheumatoid arthritis (RA), multiple sclerosis (MS), systemic lupus erythematosus (SLE), ulcerative colitis (UC), and other processes of inflammation, such as sepsis and thrombosis [17]. The gene discussed is PADI4; the disease is systemic lupus erythematosus.