IL-17 can induce the production of an array of inflammatory cytokines, chemokines, and MMP from immune and nonimmune cells, leading to the recruitment and activation of inflammatory cells with tissue damage .We suggest that IL-17 could be responsible for inflammatory tissue damage in lupus nephritis because of the increased IL-17 gene expression and excretion in the urine sediments from lupus patients [302]. Here, IL17A is linked to systemic lupus erythematosus.