Despite this, there is a suggestion that the autoimmunity in MS is more related to the class I MHC-restricted CD8+ T cells than it is to the class II-restricted CD4+ T cells [143], through the autoreactive Th1 cells which are (not fully) activated peripherally by some unknown mechanisms such as molecular mimicry with infectious agents, super antigens, and/or others. This evidence concerns the gene CD8A and Autoimmunity.