In patients with SLE, antibodies against ribonucleoproteins containing U1RNA (Sm, RNP, and U1RNP68 autoantigens) or Y1RNA (SSA/Ro52, SSA/Ro60, and SSB/La autoantigens) and the ICs containing these ribonucleoproteins circulate [40]. Here, TRIM21 is linked to systemic lupus erythematosus.