Figure 4(a) showed that the IHC scores of membranous EpEX and EpICD tended to be higher in the pSS patients over 44 years old. And the patients who suffered the disease over 1 year usually had higher IHC scores of membranous and cytoplasmic EpICD (Figure 4(b)). Among the patients who complained of xerostomia, membranous IHC scores of EpICD in LSG were higher (Figure 4(c)). And in the anti-Ro/SSA positive patients, membranous IHC scores of EpICD were higher (Figure 4(d)). This evidence concerns the gene TRIM21 and xerostomia.