In the present study, we analyzed the possible associations of polymorphisms in cytokine gene representative of Th1 and Th2 immune responses, including TNF -308, IFNG +874, IL6 -174, IL10 -1082, IL10 -819, IL10 -592, and TGFB1 codon10 and TGFB1 codon25, with the development of DLBCL and progression of the disease in patients treated with R-CHOP. This evidence concerns the gene IFNG and diffuse large B-cell lymphoma.