Through this model, the genotypes C/T or T/T and C/A or A/A of the IL10 -819 and IL10 -592, respectively, are indicated to be a risk factor for the development of DLBCL in relation to the C/C genotypes of both SNPs (OR: 2.23, P = 0.013). This evidence concerns the gene IL10 and diffuse large B-cell lymphoma.