The risk of developing DLBCL was even higher when comparing individuals with three risk genotypes (C/T or T/T and C/A or A/A of the IL10 -819 and IL10 -592, respectively, and the A/A of the IFNG +874) to those with only two, one or none of these genotypes. The gene discussed is IL10; the disease is diffuse large B-cell lymphoma.