The MAPK signaling pathway, apoptosis, pathways in cancer, cell cycle, p53 signaling pathway, calcium signaling pathway, wnt signaling pathway, adherens junction, ErbB signaling pathway, focal adhesion, regulation of actin cytoskeleton, ubiquitin-mediated proteolysis, TGF-beta signaling pathway, and pancreatic cancer interacted with more than 10 pathways, making these core pathways. This evidence concerns the gene TP53 and familial pancreatic carcinoma.