The 15-gene signature (ATP1B1, TRIM14, FAM64A, FOSL2, HEXIM1, MB, L1CAM, UMPS, EDN3, STMN2, MYT1L, IKBKAP, MLANA, MDM2, and ZNF236) can differentiate high- and low-risk subgroups with significantly different overall survival and is prognostic for both adenocarcinoma and squamous cell carcinoma cases [8]. This evidence concerns the gene EDN3 and adenocarcinoma.