RRM2 and non-small cell lung carcinoma: Examination of the expression patterns of these signature mRNAs revealed that RRAGB, RSPH9, and RXFP1 mRNA levels were significantly lower and RPS6KL1, RTL1, and RRM2 mRNA levels were significantly decreased in NSCLC of TCGA-LUAD, compared with the normal control (Figure 8(a)).