In ROC curve analysis, FOXM1 (AUC = 0.654, sensitivity = 0.533, and specificity = 0.688), CCNA2 (AUC = 0.655, sensitivity = 0.81, and specificity = 0.433), AUPKA (AUC = 0.621, sensitivity = 0.623, and specificity = 0.584), CDKN3 (AUC = 0.613, sensitivity = 0.941, and specificity = 0.292), and CDC20 (AUC = 0.686, sensitivity = 0.697, and specificity = 0.632) had certain predictive value for the 3-year survival rate of HCC patients. This evidence concerns the gene CDC20 and hepatocellular carcinoma.