We also found that the rs3209637 C genotype of ATP2B2 (OR = 1.24, 95%CI = 1.01–1.52, P = 0.045) was significantly relative with a higher NIHL risk in which the result is a powerful evidence for our hypothesis that ATP2B2 polymorphisms could increase the NIHL susceptibility in the Chinese employees. Here, ATP2B2 is linked to noise induced hearing loss.