ABCB11 and progressive familial intrahepatic cholestasis: ABCB11 is the main bile salt transporter in hepatocytes that is expressed at the apical membrane of hepatocytes, and when dysfunctional leads to various cholestatic disorders including intrahepatic cholestasis in pregnancy (ICP), progressive familiar intrahepatic cholestasis (PFIC), and transient neonatal cholestasis [1, 3–6].