MMP-15 is classified into the membrane-type MMPs that are important for pericellular proteolysis, and the expression level of MMP-15 is associated with tumor growth of human fibrosarcoma and gastric cancer cells as well as tumor progression and intratumoral angiogenesis in non-small-cell lung cancer [74, 76, 77]. The gene discussed is MMP15; the disease is fibrosarcoma.