NUMA1 and neoplasm: Numerous commercially available urine tests for urine borne biomarkers include BTA TRAK, ImmunoCyt/uCyt+, CxBladder, Nuclear Matrix Protein 22 (NMP-22) and UroVysion (FISH), although these may miss a significant proportion of patients with bladder cancer particularly when its accuracy is poor for low-stage and low-grade tumours [21].