In summary, our current study demonstrated that THSWD could slightly improve the cardiac function after MI, but significantly increased the expression of IGF-1 and bFGF, reduced collagen deposition, promoted angiogenesis, reduced the cell apoptosis, activated PI3K/Akt signaling pathway, and decreased the mitochondrial ROS production and Fis1 expression. This evidence concerns the gene FGF2 and myocardial infarction.