EIF4E and breast carcinoma: eIF4E has great influence on cell proliferation, differentiation and metastasis.210 Studies have shown that eIF4E is overexpressed in many malignant cell lines and primary tumors in animals and humans, including breast cancer, lung cancer, and non-Hodgkin’s lymphomas among others.211 It has been reported that inhibition of eIF4E function can slow tumor growth and induce apoptosis.212 Therefore, the development of novel eIF4E degraders is a new strategy for the treatment of many cancers.213,214