p53, a tumor suppressor, plays a pivotal role in many cellular processes regulation and the cancer development prevention.274 However, mutations or deletions of p53 occur in approximately 50% of human cancers resulting in inactivation of p53 tumor suppressor function.275 Murine double minute 2 (MDM2) is a negative endogenous cellular regulator of p53. Here, TP53 is linked to cancer.