PIK3CA and cancer: Once bound to HGF/SF, c-Met dimerizes, and transphosphorylation happens in the kinase domain (Y1234 and Y1235) and C-terminal docking domain (Y1313, Y1349, Y1356, and Y1365).197 The docking domain recognizes many downstream cellular effectors, including Src, Gab1, Crk, Grb2, SHC, and PI3K, which play important roles in cancer biology.