ALK and non-small cell lung carcinoma: In the same year, Jian Jin and coworkers reported two ALK-targeting PROTACs, MS4077 and MS4078, through connecting ceritinib and pomalidomide with two distinct linkers (Fig. 6).123 In addition to degrading NPM-ALK and EML4-ALK, MS4077 and MS4078 could inhibit ALK and STAT3 phosphorylation in concentration- and time-dependent manners in both SU-DHL-1 (ALCL cells harboring NPM-ALK) and NCI-H2228 cells (NSCLC cells harboring EML4-ALK).