In 2019, the Weiping Tang group reported the second MDM2 degrader, degrader 32, through connection of MDM2 ligand (nutlin) and CRBN E3 ligase ligand (lenalidomide) (Fig. 30).277 Degrader 57 induced efficient degradation of MDM2 with a DC50 value of 23 nM in RS4;11 leukemia cells. This evidence concerns the gene MDM2 and leukemia.