FN1 and neoplasm: Among tumor-associated stromal cells, CAFs constitute the bulk of solid tumor stroma and contribute to tumor progression and therapeutic response.42 Furthermore, tumor cells are known to be influenced by the composition, organization and mechanical properties of the microenvironment as well as by molecular signals released by stromal cells.43 In this regard, CAFs are important because they synthesize the majority of ECM proteins, including fibrillar collagens and fibronectin, to promote matrix stiffening.