However, studies of tau radioligands have so far not been proven to be particularly helpful in FTD, binding much more strongly to paired helical filament (PHF)-tau found mainly in Alzheimer’s disease70,71 than to other forms of tau found in the primary tauopathies such as progressive supranuclear palsy72–75 or corticobasal degeneration76–78. Here, MAPT is linked to frontotemporal dementia.