The results demonstrated that the associated schemes were able to reverse short-term and long-term memory deficits and control the increase of AChE in PFC, HC, and ST, effectively with the same or more than isolated substances, thus suggesting a neuroprotective effect of the combination between α-LA and desvenlafaxine, given that AChE is a marker for degenerative diseases [105]. This evidence concerns the gene ACHE and neurodegenerative disease.