In addition, dysfunctional mitochondria regulate inflammatory responses through the activation of inflammasomes, a multicomplex protein that comprises nucleotide-binding domain activation, leucine-rich-containing family, pyrin domain-containing-3 (NLRP3) and sites where pro-IL-1β and pro-IL-18 processing take place, generating the activation of IL-1β and caspase-1, which is a crucial mechanism in the pathology of AD [49]. The gene discussed is IL1B; the disease is Alzheimer disease.