Our findings demonstrated a scenario where FA-97 promotes the nuclear translocation of Nrf2 and the expression of its downstream target proteins HO-1 and NQO-1, to reduce the ROS level, enhance the oxidant resistance, and eventually protect against oxidative stress-mediated neuronal cell apoptosis and scopolamine-induced cognitive impairment (Figure 9). The gene discussed is HMOX1; the disease is Cognitive impairment.