3-(2-Oxo-2-phenylethylidene)-2,3,6,7-tetrahydro-1H-pyrazino[2,1-a] isoquinolin-4(11bH)-one, a novel potent Nrf2/ARE inducer, has been found to protect against DSS-induced colitis via inhibiting the NLRP3 inflammasome [53]. This evidence concerns the gene NFE2L2 and colitis.